抗精神病药物联合心理干预对精神分裂症患者认知和社会功能的影响

The effect of antipsychotic drugs combined with psychological intervention on cognitive and social function in schizophrenic patients

目的探讨抗精神病药物联合心理干预对精神分裂症患者认知和社会功能的影响。方法将120例精神分裂症患者分为对照组和干预组,对照组给予帕利哌酮治疗,干预组给予帕利哌酮联合心理干预,观察入组前和入组后4、8和12周末采用阳性与阴性症状量表(PANSS)评定精神分裂症症状的严重程度,采用韦氏成人记忆量表(WMS)评定认知状况,采用个人和社会功能量表(PSP)评定社会功能。结果入组后12周时干预组患者脱落率(10.7%)低于对照组(28.6%)(P<0.059)。2组患者入组后4、8及12周时PANSS评分递减,WMS、PSP评分递增,差异有统计学意义(P<0.05或P<0.01)。入组后12周时干预组PANSS评分低于对照组(P<0.01),入组后8、12周时干预组WMS、PSP评分高于对照组(P<0.01)。2组不良反应事件发生情况差异无统计学意义(P>0.05)。结论抗精神病药物联合心理干预可改善精神分裂症患者的认知和社会功能,提高治疗依从性。

Objective To discuss the effect of antipsychotic drugs combined with mental intervention on cognitive and social function in schizophrenic patients.Methods A total of 120 schizophrenic patients were divided into intervention（n = 56） and control group（n = 64） and with paliperidone,and psychological intervention were applied to intervention group.The severity of schizophrenia was assessed by positive and negative syndrome scale（PANSS） before onset and 4,8 and 12 weeks after intervention,respectively.The cognitive and social function were evaluated by wechsler memory scale（WMS） and personal and social performance scale（PSP）.Results The loss rate was lower in intervention group（10.7%） than that in control group（28.6%）,with a significant difference（P〈 0.05）.There was an decline in PANSS and increase in WMS and PSP between 4 and 12 weeks after intervention（P〈 0.05,P〈 0.01）.Compared with control group,intervention group achieved lower PANSS at 12 weeks and higher WMS and PSP at 8 and 12 weeks.There was no significant difference in incidence of adverse events between two groups（P〉0.05）.Conclusion Combination treatment of antipsychotic drugs and psychological intervention can improve the cognitive and social function in schizophrenic patients.