持续口服西甲硅油对胶囊内镜图像质量的影响

Effect of Continuous Taking Simethicone Orally on Image Quality of Capsule Endoscopy

目的探讨持续口服西甲硅油对胶囊内镜图像质量的影响。方法选择在波市第四医院接受OMOM胶囊内镜检查的患者124例,采用随机数字表法分为两组,观察组(60例)在检查当日将西甲硅油30 ml加入2 000 ml聚乙二醇电解质散溶液口服。对照组(64例)在检查前1 d开始口服西甲硅油10 ml,3次/d,检查当日开始口服聚乙二醇电解质散溶液,检查前30 min再次口服西甲硅油10 ml。定量分析两组患者胶囊内镜检查图像的气泡量、消化液量、清洁度,同时观察患者不良反应发生率。结果对照组和观察组患者检查胶囊进入小肠时间分别为(52.1±27.5)min和(45.8±30.5)min,差异无统计学意义(t=-1.209,P=0.223);在小肠内运行时间分别为(363.3±51.4)min和(345.4±42.5)min,差异无统计学意义(t=1.657,P=0.147)。观察组患者小肠下段及全段气泡量评分、清洁度评分及综合评分少于对照组(P<0.05)。对照组不良反应发生率(17.2%,11/64)高于观察组(5.0%,3/60)(χ2=4.590,P<0.05)。结论将西甲硅油加入聚乙二醇电解质散溶液持续口服可以显著改善胶囊内镜图像质量,减少不良反应发生率。

Objectjve To observe the influence of continuous taking simethicone orally on image quality of capsule endoscopy. Methods 124 patients who underwent OMOM capsule endoscopy in Ningbo Fourth Hospital were divided into observation group（60 cases）and control group（64 cases）by random number table method. On the examination day,cases in observation group took mixed liquid of simethicone（30 ml）and polyethylene glycol electrolyte solution（2 000 ml）;one day before examination day,cases in control group took 10 ml of simethicone three times a day,then took polyethylene glycol electrolyte solution on the examination day,and took 10 ml of simethicone again 30 min before examination. The image quality of endoscopy was graded according to the number of bubbles,the quantity of residual liquid in small intestine and cleanness. The adverse reactions were also observed. Results There was no significant difference in pylorus transit time or small bowel transit time between observation group and control group〔（52. 1 ± 27. 5）min vs. （45. 8 ± 30. 5） min,t = - 1. 209,P = 0. 223;（363. 3 ± 51. 4）min vs. （345. 4 ± 42. 5）min,t = 1. 657,P = 0. 147〕. The score of number of bubbles,cleanliness scorenbsp;and comprehensive score of the lower small intestine and the whole small intestine in observation group were significantly lower than those in control group（ P 〈 0. 05）. The occurrence rate of adverse reactions in control group（17. 2% ,11 / 64）was significantly higher than that（5. 0% ,3 / 60）in observation group（χ2 = 4. 590,P 〈 0. 05）. Conclusjon Continuous taking mixed liquid of simethicone and polyethylene glycol electrolyte solution can significantly improve the image quality of capsule endoscopy and can reduce the occurrence rate of adverse reactions.