柳氮磺吡啶与奥沙拉嗪治疗溃疡性结肠炎的对比研究

Comparative Study on Sulfasalazine and Olsalazine Medication Treatment of Ulcerative Colitis

目的：对比柳氮磺吡啶与奥沙拉嗪治疗溃疡性结肠炎的临床效果。方法搜集2013年12月～2014年12月我院溃疡性结肠炎患者38例，根据治疗用药不同分成两组。研究组共19例，治疗药物选择奥沙拉嗪；对照组共19例，治疗药物选择柳氮磺吡啶。观察对比两组效果。结果与对照组相比，研究组治疗有效率较高（P〈0.05），不良反应的发生率较低（P〈0.05），差异显著。结论奥沙拉嗪治疗溃疡性结肠炎的临床效果优于柳氮磺吡啶，且不良反应少。

Objective Clinical effects on sulfasalazine and olsalazine medication in treatment of ulcerative colitis are to be comparatively studied. Methods We chose 38 patients of ulcerative colitis who were treated in hospital from December 2013 to December 2014 and separated them into two groups according to different medication treatment methods,nineteen patients in study group were given olsalazine medication treatment,while 19 patients in control group were given sulfasalazine medication treatment,and then compared treatment effects between two groups. Results Compared to control group,treatment efficacy in study group was much higher（P〈0.05）,and side-effect incidence in study group was much less（P〈0.05）,there was a significant treatment differential between two groups. Conclusion Compared to sulfasalazine medication treatment,olsalazine medication is much more effective in treatment of ulcerative colitis with few side effects.