子宫肌瘤不同术式对内分泌影响的研究

Influence of Different Hysteromyoma Surgical Types on Endocrine Secretion

目的：探讨子宫肌瘤不同术式对内分泌的影响。方法选取2012年1月～2014年12月我院收治的50例子宫肌瘤患者，并根据术式的不同分为甲、乙、丙三组。甲组17例患者行保留附件子宫全切术，乙组17例患者行保留附件子宫次全切除术，丙组16例行子宫肌瘤剔除术，观察并比较三组患者手术前后黄体生成素（LH）、促卵泡激素（FSH）、雌二醇（E2）的变化。结果手术后甲、乙、丙三组都表现为：LH及FSH水平升高和E2水平下降，但是丙组（子宫肌瘤剔除术组）手术前后LH、FSH、E2水平前后比较差异不显著，P〉0.05，另外两组这三项指标在术后3个月与术前相比差异显著，P〈0.05，在术后6个月与术前相比差异不显著，P〉0.05。结论子宫肌瘤不同术式对内分泌都会有一定的影响，但是影响最小的是子宫肌瘤剔除术，在为患者选择手术方式时要根据患者的实际情况，力求在确保肿瘤有效切除的情况下，保留患者的内分泌功能，保证患者的术后生活质量。

Objective To explore the influence of different hysteromyoma surgical types on endocrine secretion. Methods Fifty patients with hysteromyoma treated in our hospital from January 2012 to December 2014 were selected for this research,and they were divided into three groups,namely,Group A,B and C,seventeen patients in group A were treated with hysterectomy with adnexa uteri not removed,seventeen patients in group B were treated with subtotal hysterectomy with adnexa uteri not removed,sixteen patients in group C were treated with hysteromyomectomy. LH（luteinizing hormone）,FSH（fol icle-stimulating hormone）and E2（estradiol）in patients of these groups were observed and compared before and after surgery. Results For patients in groups A,B and C,the level of LH and FSH rose and the level of E2 fel . There was no significant change in the levels of LH,FSH and E2 in patients in Group C（treated with hysteromyomectomy）,with P〉0.05,while the changes of those levels before surgery and three months thereafter were significant in patients in the other two groups,with P〈0.05,and those changes were not significant between those before surgery and six months thereafter,with P〉0.05. Conclusion Different operation types for hysteromyoma al have certain influence on endocrine secretion,and hysteromyomectomy has the least impact. It is better to decide which surgical type to take according to patient’s individual situations, and strive to retain patient’s endocrine functions and ensure their post-surgery living quality.