儿童感染性眼病的病原菌分布特征及耐药性分析

The pathogenic bacteria distribution and drug resistance analysis of children infectious eye disease

目的探讨儿童感染性眼病的感染病原菌菌群分布及药敏分析。方法回顾性分析2010年12月至2014年2月我院眼科门诊及住院部的526例感染性眼病的患儿的临床资料。结果送检病原体标本的培养阳性数共为157例,培养阳性率为29.8%。其中细菌标本134例(占85.3%),真菌标本21例(占13.4%),阿米巴2例(占1.3%)。阳性标本的年龄分布≤l岁的标本数最多且全部为细菌感染;共培养鉴定出细菌206株,其中革兰阳性球菌占45.6%,革兰阴性杆菌占15.5%。培养的细菌中,淋球菌比例最高,占18.4%,且均来自1岁以下幼儿。1岁以上幼儿最常见为表皮葡萄球菌(17.9%)。培养阳性细菌中,左氧氟沙星及利福平的药物敏感性显著高于其他药物;培养阳性的真菌中,对那他霉素敏感性最高。结论儿童感染性眼病致病因素和病原菌的分布与成人相比,均有所不同,所以眼科医师要更深入全面了解其病原菌的分布和敏感性药物的特点。

Objective To study the infection of children infectious eye disease pathogen bacteria distribution and drug susceptibility analysi. Methods From December 2010 to December 2014 clinical data of 526 cases of chil- dren were retrospectively analyzed. Results There were pathogens specimen culture positive for a total of 157 ca- ses, cultivate positive rate was 29.8%. The bacteria specimens of 134, accounting for 85.3% ; Fungi specimens were 21 （13.4%） ; 2 cases were Amoeba, accounting for 1.3%. The age distribution of positive samples was as follows ： 1 years old or less on the number of positive specimens, all as a bacterial infection ; A total of 206 strains bacteria culture identification, including gram - positive cocci accounted for 45.6% ; Gram negative bacteria ac- counted for 15.5%. Culture of bacteria, had the highest percentage of neisseria gonorrhoeae, 18.4% , and were from children under the age of one year old. Above the age of one year old, the most common was Epidermis staph- ylococcus （ 17.9% ）. Culture in a positive bacteria, Levofloxacin and Rifampicin drug sensitivity were significantly higher than other drugs; Fungal culture positive, the drug sensitivity was highest for Natamycin. Conclusion Children infectious eye disease risk factors and pathogenic bacteria distribution compared with adults, are different. So ophthalmologist to further a comprehensive understanding of the characteristics of the distribution of pathogenic bacteria and drug sensitivity.