利鲁唑的神经保护作用及其机制的研究进展

Riluzole's Neuroprotective Effect and the Mechanisms

利鲁唑(2-氨基-6-三氟甲氧基-苯并噻唑)属苯并噻唑类化合物,具有明确的神经保护药理作用。它的主要作用是抑制多种受体和离子通道介导的谷氨酸突触传导和神经元超兴奋性,提高神经营养因子的表达量,保护神经元免受兴奋毒性损伤,促进神经元的存活。该文就利鲁唑神经保护作用及其机制的相关研究进展进行综述。

Riluzole（2-p-aminophenyl-6-substituent-benzothiazole） is a benzothiazole compound,which has definite neuroprotective effect.The main mechanisms underlying this effect are likely to be multifaceted , involving suppressing glutamate neurotransmission and neuronal hyperexcitation,promoting the expressing of nerve growth factors via the function of a variety of receptors and related ion channel ,protecting neurons from toxicological damage.Here is to make a review of neuroprotective effect and mechanisms of riluzole to pro-vide a basis for further study.