不合并肺动脉高压的慢性阻塞性肺疾病患者血浆脑钠肽水平的研究进展

Research Progress of Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease without Pulmonary Hypertension

慢性阻塞性肺疾病(COPD)高患病率、高病死率,给社会经济造成沉重负担。COPD急性加重是目前患者住院治疗的主要原因,直接影响发病率和病死率。急性加重会对COPD患者产生长远影响,如炎症加重、肺功能进行性减退和气道定植菌及耐药菌感染机会增加等。目前,脑钠肽的研究主要集中于心脏疾病,在肺脏疾病鲜有研究。

Chronic obstructive pulmonary disease（COPD） brings a heavy burden to the social economy because of its high morbidity and mortality.Acute exacerbation of COPD（AECOPD） is the main cause of hospitalization and a direct impact on morbidity and mortality .AECOPD has long-term impact on COPD patients,such as aggravated inflammation,reduced lung function and increased chance of airway engraftment bacteria and drug-resistant bacteria infection.Research on brain natriuretic peptide is mainly focused in the heart diseases,while it’ s rare in the lung diseases.