多囊卵巢综合征病因与病机及诊断研究进展

Advances in Etiology,Pathogenesis and Diagnosis of Polycystic Ovary Syndrome

多囊卵巢综合征（PCOS）是生育期女性最常见的内分泌失调疾病,育龄妇女中发病率为5%~10%,现今其发病率有所上升。PCOS的病因众多,普遍认为PCOS是由多个微效基因与环境因素相互作用而引起的一种多基因遗传性疾病;此外,肥胖、高胰岛素血症者患PCOS的概率也会增加,而精神心理因素对PCOS的发病也有一定的影响。其发病机制复杂,最重要的是与雄激素分泌过量、胰岛素抵抗密切相关。

Polycystic ovary syndrome（PCOS） is one of the most common endocrine disorders affecting women of reproductive age with an incidence of 5%-10%of them,which has been rising.PCOS has a diverse range of causes.It is widely believed that PCOS is a polygenic hereditary disease caused by the interaction of multiple minor genes and environment factors;besides,obesity and hyperinsulinemia may increase the risk of PCOS,while psychological factors have a certain influence on PCOS as well .The pathogenesis of PCOS is complicated and closely related to excessive androgen secretion and insulin resistance in particular .