利尿剂在心力衰竭中的治疗进展

Research Advances in Diuretic Therapy for Heart Failure

心力衰竭(心衰)指心脏结构或功能性疾病导致心室充盈及(或)射血能力受损而引起的一组综合征。利尿剂在心力衰竭治疗中占重要地位,是治疗急性呼吸困难和维持慢性心衰血容量稳定的一线用药。合理使用利尿剂是其他治疗心衰药物取得成功的关键因素之一。利尿剂种类较多,近年有关利尿剂治疗心衰的研究不断涌现,尤其是托拉塞米、醛固酮受体拮抗剂、托伐普坦等在心衰治疗中的应用有较多的文献报道,该文就相关研究进展予以综述。

Heart failure refers to a series of clinical syndromes of impaired ability of the ventricle to fill or eject blood results from abnormality of cardiac structure or functional diseaseshe.Diuretics play an importantrole in heart failure therapy,they are the first-line drugs in treating acute dyspnea and maintaining thestability of blood volume in patients with chronic heart failure.The rational use of diuretics is one of the keyfactors that influence on the successfulness of other medicines in treating heart failure.In recent years,researcheson diuretics in treating heart failure are constantly emerging,especially on torasemide,aldosterone receptorantagonists,tolvaptan,etc.Here is to make a review of the advances in such researches .