依折麦布及其联合治疗的研究进展

Research Progress of Ezetimibe and Its Combination with Statins

依折麦布作为小肠胆固醇吸收抑制剂,在降低总胆固醇、低密度脂蛋白胆固醇、三酰甘油及载脂蛋白B的同时,可提升高密度脂蛋白胆固醇水平;此外,依折麦布尚有抗炎、抗动脉粥样硬化等作用,可进一步降低心血管事件风险;且依折麦布在具有较高安全性的同时,不升高血清前蛋白转化酶枯草溶菌素9的水平,故而不影响血清低密度脂蛋白胆固醇的代谢。该文就依折麦布的作用机制、单用及与他汀联合用药的研究进展予以综述。

Ezetimibe,a recognized intestinal cholesterol absorption inhibitor,can reduce the levels of total cholesterol,triglyceride,low-density lipoprotein chdesterol and apolipoprotein B,while enhancing the high-density lipoprotein chdesterol level.In addition,ezetimibe has been reported to play a role in prevention from inflammation,atherosclerosis,which further reduces the risks of cardiovascular events.Besides the high safety,ezetimibe does not increase the serum level of proprotein convertase subtilisin/kexin type 9,which doesn′t influence the metabolism of low-density lipoprotein cholesterol.Here is to make a review of the research progress in the functioning mechanisms,single application and combined application with statins of ezetimibe.