可溶性细胞间黏附分子1和促红细胞生成素及血管内皮生长因子在多发性骨髓瘤患者的表达与临床意义

Study on the Expressions of Soluble Inter-cellular Adhesion Molecule-1,Erythropoietin and Vascular Endoehelial Growth Factor in Multiple Myeloma and Their Clinical Significance

目的探讨多发性骨髓瘤(MM)患者血清中可溶性细胞间黏附分子1(s ICAM-1)、促红细胞生成素(EPO)和血管内皮生长因子(VEGF)的表达水平及其临床应用价值。方法选择2011年7月至2013年4月在惠州市第一人民医院治疗的MM患者64例(MM组)及24例健康体检者(健康对照组)为研究对象,分析MM组及健康对照组、不同临床分期及不同肿瘤量患者血清s ICAM-1、EPO及VEGF的表达水平。结果健康对照组血清s ICAM-1、EPO及VEGF表达水平分别为(287±81)μg/L、(14±6)U/L、(113±78)mg/L,MM组患者血清s ICAM-1、EPO及VEGF表达水平分别为(375±102)μg/L、(36±14)U/L、(614±205)mg/L。MM组患者血清s ICAM-1、EPO及VEGF表达水平均显著高于对照组(P<0.05);随着临床分期的增加,患者血清中s ICAM-1、EPO及VEGF呈增加趋势,差异均有统计学意义(P<0.05);随着患者肿瘤量的增加,血清中s ICAM-1、EPO及VEGF表达水平也显著升高(P<0.05)。结论 ICAM-1、EPO及VEGF在MM患者血清中呈现出高表达,且随着病程的加剧显著升高。因此,血清ICAM-1、EPO及VEGF表达水平的升高对于MM患者临床分期的判断及辅助监测患者病情进展情况有重要的参考价值。

Objective To investigate the expression levels of soluble inter-cellular adhesion molecule-1 （sICAM-1）,erythropoietin（EPO） and vascular endoehelial growth factor（VEGF） in serum of patients with multiple myeloma（MM） and their clinical significance.Methods A total of 64 MM patients admitted in Huizhou First People＆#39;s Hospital from Jul.2011 to Apr.2013 were selected as MM group and another 24 cases of healthy volunteers underwent physical examination during the same period in the hospital were selected as the control group.The serum expression levels of sICAM-1,EPO and VEGF in patients of different clini-cal stages and tumor volumes from both groups were analyzed.Results The serum expression levels of sICAM-1, EPO and VEGF in the control group were （287±81） μg/L,（14 ±6） U/L,（113 ±78） mg/L, and those in MM group were （375 ±102） μg/L,（36 ±14） U/L,（614 ±205） mg/L.Such expression lev-els of MM group were significantly higher than the control group （P〈0.05）;as the clinical stage rose,the serum expression levels of sICAM-1, EPO and VEGF showed an increasing trend,the differences were statis-tically significant（P〈0.05）;and along with the increase in tumor volumes of the patients,the serum expres-sion levels of sICAM-1, EPO and VEGF also significantly elevated（P〈0.05）.Conclusion ICAM-1,EPO and VEGF are highly expressed in the serum of patients with MM,and their expression levels significantly elevate along with the increasing of clinical stage and tumor volume ,which can provide important guidance for the determination of clinical stage of patients with multiple myeloma and auxiliary monitoring on the patients ’ situation.