甲羟孕酮治疗卵巢子宫内膜异位囊肿术后患者临床效果观察

Clinical Observation on the Effect of Medroxyprogesterone in the Treatment of Patients after Ovarian Endometriosis Cyst Surgery

目的分析孕激素(甲羟孕酮)对卵巢子宫内膜异位囊肿术后患者的治疗效果。方法将2001年10月到2005年8月呼伦贝尔市中蒙医院手术后病理确诊为子宫内膜异位囊肿的73例患者采用随机数字表法进行随机分组,无药物治疗组31例,无任何药物治疗;甲羟孕酮治疗组42例,使用孕激素治疗,术后第5日肌内注射孕激素甲羟孕酮150 mg,每月1次,连续用药6个月。追踪入组患者12个月,观察两组患者腹痛、痛经程度、异位囊肿复发时间、复发囊肿大小等临床指标。结果甲羟孕酮治疗组3、6、12个月疗效显著高于无药物治疗组(P<0.05)。无药物治疗组月经恢复时间显著短于甲羟孕酮治疗组[(65±8)d比(235±10)d,P<0.05]。结论孕激素(甲羟孕酮)对卵巢子宫内膜异位囊肿患者治疗有效。

Objective To study the clinical efficacy of progestin （ medroxyprogesterone） in the treatment of patients after ovarian endometriosis cyst surgery .Methods A total of 73 patients diagnosed with ovarian endometriosis cyst in Chaoyang District Second Hospital from Oct.2001 to Aug.2005 were divided into two groups by the random number table method：patients in the control group （ 31 cases ） received no drug therapy, while patients in medroxyprogesterone group（42 cases） received medroxyprogesterone therapy,the first injections of 150 mg medroxyprogesterone were given at the fifth day after surgery,the following injec-tions were given with an interval of 1 month each time,and proceeded for 6 months.The clinical clinical indi-cators of celialgia,dysmenorrheal,recurrence time of endometrioma,size of recurrent cyst were recorded and analyzed.Results The curative effects at the 3rd,6th,12th month of the medroxyprogesterone group was sig-nificantly higher than that of the control group（P〈0.05）.The menstrual recovery time of the control group was significantly shorter than the medroxyprogesterone group [ （ 65 ±8 ） d vs （ 235 ±10 ） d, P 〈0.05 ] . Conclusion Pogestin（medroxyprogesterone） is effective in the treatment of patient with ovarian endometrio-sis cyst.