雄激素受体在激素依赖性肿瘤中的研究进展

Research Progress of Androgen Receptor in Hormone-dependent Tumors

雄激素受体(AR)是类固醇激素受体家族成员,属于受配体激活的细胞内转录因子。AR在激素依赖性肿瘤中发挥重要作用。近年来对AR的研究发现,其既可以在胞质中调控信号通路,也可以在胞核内直接调控相关靶基因,从而参与肿瘤增殖、侵袭、细胞周期改变等过程。目前只有少数AR相关性药物应用于部分激素依赖性肿瘤,总结及深入研究AR作用机制能进一步推进AR靶向治疗在激素依赖性肿瘤中的应用。

Androgen receptor（ AR）, a member of the family of steroid hormone receptors, is a cellular transcriptional factor activated by ligands. AR plays an important role in hormone-dependent tumors. In recent years, the researches have found that AR is involved in tumor progression such as cell proliferation, invasion, cell cycle by influencing signaling pathways in cytoplasm or by regulating its target genes in nucleus. Nowa- days, only a few drags related to AR are used in part of hormone-related tumors. Summarizing and deeply investigating AR function mechanisms are helpful to improve the application of the AR targeting therapy.