机械牵张力对破骨细胞的影响

The Impact of Mechanical Strain on Osteoclasts

骨的生长或吸收由成骨细胞及破骨细胞共同控制,而破骨细胞在骨的吸收过程中起主要的作用;破骨细胞的增多与减少与机械牵张力的作用密切相关,改变不同机械牵张力,包括机械振动、压载荷、力学拉伸力和流体剪切力等,对破骨细胞作用的时间、强度等,即可改变破骨细胞的相应特性,从而改变破骨细胞的功能活性。研究牵张力与破骨细胞的关系,将使牵张力在临床工作中的治疗作用得到重视。

Bone growth or absorption is controlled by the osteoblasts and osteoclasts, and osteoclasts play an important role in the absorption process of the bone; esteoclasts increase or decrease is closely related to the change of the difference of mechanical strain. Changes of the type of mechanical strain,inclnding mechan- ical vibration, pressure loads, mechanical strain and fluid shear stress, can change the structures of cytoskele- ton and biological nature of extracellular matrix, and then affect the osteoclasts＇ physiologic property. By stud： ying the relations of mechanical force and osteoclasts, the therapy of mechanical force will get more attention in clinical.