摘要
骨的生长或吸收由成骨细胞及破骨细胞共同控制,而破骨细胞在骨的吸收过程中起主要的作用;破骨细胞的增多与减少与机械牵张力的作用密切相关,改变不同机械牵张力,包括机械振动、压载荷、力学拉伸力和流体剪切力等,对破骨细胞作用的时间、强度等,即可改变破骨细胞的相应特性,从而改变破骨细胞的功能活性。研究牵张力与破骨细胞的关系,将使牵张力在临床工作中的治疗作用得到重视。
Bone growth or absorption is controlled by the osteoblasts and osteoclasts, and osteoclasts play an important role in the absorption process of the bone; esteoclasts increase or decrease is closely related to the change of the difference of mechanical strain. Changes of the type of mechanical strain,inclnding mechan- ical vibration, pressure loads, mechanical strain and fluid shear stress, can change the structures of cytoskele- ton and biological nature of extracellular matrix, and then affect the osteoclasts' physiologic property. By stud: ying the relations of mechanical force and osteoclasts, the therapy of mechanical force will get more attention in clinical.
出处
《医学综述》
2015年第9期1552-1554,共3页
Medical Recapitulate
基金
云南省科学技术厅基金(2010ZC223)
关键词
机械牵张力
破骨细胞
拉伸强度
力学性能
Mechanical force
Osteoclasts
Tensile strength
Mechanical properties