慢性阻塞性肺疾病急性加重期应用糖皮质激素治疗的进展

Research Progress on Glucocorticoid Therapy for Acute Exacerbation Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是以进行性不完全可逆的气流阻塞为特征的疾病。COPD急性加重更是导致患者死亡和致残的主要原因。经大量临床试验证实,在对COPD患者进行抗感染、氧疗、祛痰、舒张支气管等基础治疗的基础上,加用糖皮质激素可显著改善患者的临床症状,加快病情好转,缩短住院时间,减少急性加重发作的频率,提高生活质量。

Chronic obstructive pulmonary disease （COPD） is a progressive disease characterized by incompletely reversible airflow restriction. And acute exacerbation chronic obstructive pulmonary disease （AECOPD） is the major cause of mortality and disability of the patients. A large number of clinical trials on COPD have confirmed that on the basis of anti-infection treatment, oxygen therapy, expectorant, bronchodila- tor,etc, additional application of inhaled corticosteroids can significantly relieve the symptoms, accelerate condition improvement, shorten the duration of hospital stay, decrease the frequancy of recurrent exacerbations and improve the quality of life in patients with COPD.