白细胞介素-10-1082G/A基因多态性与结核病易感性关系的Meta分析

Association of IL-10-1082G/A Gene Polymorphism with Tuberculosis Risk:A Meta-Analysis

目的:研究白细胞介素-10-1082G/A基因位点多态性与结核病易感性的关系。方法:利用PubMed、Medline、EMbase等数据库检索相关文献。采用筛选标准和方法学质量评价,纳入符合要求的文献,并采用Stata12.0软件进行Meta分析,计算合并OR值及其95%CI,最后进行敏感性分析及发表偏倚评估。结果:共26篇文献纳入研究,其中病例组(结核病患者)5 949例,对照组(健康体检者)6 948例。Meta分析结果显示,在各个遗传模型中,IL-10-1082G/A基因多态性与结核病总体发病风险关系不大。对纳入研究以种族为分层因素进行分析,在欧洲人群中GG纯合子基因型者结核病发病率高于AG+AA基因型者(OR=1.69,95%CI=1.19-2.39,P<0.05)。对纳入研究以疾病类型为分层因素进行分析,GG纯合子基因型者肺结核与肺外结核发病率高于AA纯合子基因型者(OR=2.00,95%CI=1.16-3.45,P<0.05)。经Begg’s与Egger’s检验,纳入的所有研究未见明显发表偏倚。结论:IL-10-1082G/A基因多态性中等位基因G可能与结核病易感性风险增高相关,这种情况可能只存在于欧洲人群及混合结核病中。

Objective：To investigate the association between interleukin-10 （IL-10）gene promoter SNP -1082G/A polymorphism and tuberculosis（TB）susceptibility.Method：Such databases as PubMed,Medline and EM-base data were searched to collect the case-control studies published.According to the inclusion and exclusion crite-ria,the studies were screened,the data were extracted,and the methodological quality of the included studies was e-valuated.Then meta-analysis was conducted using Stata 12.0 software,the pooled odds ratio （ORs）with 95%conidence interval （CI）were calculated,and the sensitivity and publication bias were evaluated at the same time.Re-sults：A total of 26 studies were included,which involved 5 949 cases and 6 948 healthy controls.The results of me-ta-analysis showed that,the IL-10-1082G/A polymorphism had no association with a increased risk of TB.In the stratified analysis by ethnicity,significantly increased risk of TB was associated with Asians in IL-10-1082G/A polymorphism （GG vs AG＋AA：OR=1.69,95% CI=1.19-2.39,P〈0.05）.We also performed the analyses by desease types in IL-10-1082A/G polymorphism,significant increased TB risk was observed in mixed group under homozygous model （GG vs AA：OR=2.00,95% CI= 1.16-3.45,P〈0.05）.All of the included studies showed no publication bias by Begg＇s and Egger＇s test.Conclusion：The results suggested that the IL-10-1082G/A polymor-phism was associated with TB increased risk in Europeans and mixed tuberculesic.