妊娠期抗生素使用情况调查及分析

Survey and Analysis of Antibiotics Using During Pregnancy

目的：初步了解妊娠期抗生素使用情况及影响因素,为孕期合理使用抗生素提供参考。方法：收集我院分娩的1 010名产妇资料,分析妊娠期抗生素使用情况及影响因素。结果：225例（22.3%）产妇在孕期至少使用一种抗生素。妊娠期最常用抗生素依次为二代头孢菌素92例（40.9%）、一代头孢菌素62例（27.6%）、青霉素类药物41例（18.2%）,其他药物30例（13.3%）。有妊娠并发症（OR=7.3,95%CI：5.0-10.7）、孕期住院（OR=3.4,95%CI：2.2-5.3）的孕妇在妊娠期间使用抗生素的风险更高。结论：妊娠期使用抗生素常见,有妊娠并发症、孕期住院等因素的孕妇妊娠期使用抗生素风险更高。

Objective：To survey current situation of antibiotics use during pregnancy, which will provide reference for the rational use of drugs during pregnancy. Methods：To collect data of 1 010 cases who deliveried in our hospital,and to analysis situation of antibiotics use during pregnancy and related factors. Results： 225 cases（22. 3 % ）have used at least one antibiotics during pregnancy. The most commonly used drugs were second-generation cephalosporins 92 cases （40. 9%）,first-generation eephalosporins 62 cases （27. 6%）, Penicillins 41 cases （18. 2%）, other drugs 30 cases （ 13.3% ）, successively. People who have pregnancy complications （OR = 7.3,95 % CI： 5.0 -10. 7 ）, hospitalization during pregnancy（OR= 3.4,95%CI： 2.2-5.3） would be at higher risk to use antibiotics during pregnancy. Conclusion： Pregnant women commonly used antibiotics in pregnancy. Pregnant women with pregnancy complications and hospitalization during pregnancy are at higher risk of using antibiotics.