AGGF1在肝癌中的表达及与预后的关系

The overexpression of AGGF1 predicts poor prognosis in hepatocellular carcinoma

目的:探索AGGF1在肝癌中的表达情况及与肝癌患者预后的关系。方法:对180例肝癌组织及癌旁组织进行AGGF1免疫组织化学检测,并对其表达与患者预后的关系进行分析。结果:AGGF1在肝癌组织中的表达比癌旁组织高(P<0.001),Kaplan-Meier曲线分析发现AGGF1表达高的患者生存较差(P=0.002)。COX回归模型分析发现AGGF1可以作为一个独立指标预测肝癌患者术后生存。结论:肝癌患者AGGF1高表达预示着较差预后,并且AGGF1可以作为一个独立因素来预测肝癌患者术后生存。

Objective：To determine the expression of AGGF1 in hepatocellular carcinoma（HCC）,investigate their relationships with the progression of hepatocellular carcinoma. Methods：All 180 HCC tissues and pericancer tissues were determine by immunohistochemistry（IHC）,prognoses of 180 patients was analysed by Kaplan - Meier curve and COX regression. Results：The expression of AGGF1 in HCC tissues was higher than the pericancer（P 〈 0. 001）. The survival rate of patients with high AGGF1 expression was poorer than patients with low AGGF1 expression（P =0. 002）. The COX model analysis found that AGGF1 expression was independent biomarker in progression of HCC pa-tients. Conclusion：The high expression of AGGF1 predict poorer prognosis in HCC patients.