膀胱癌电切术后膀胱灌注多柔比星脂质体治疗浅表性膀胱癌的疗效观察

Curative effect of doxorubicin lipidosome after TURP irrigation of superficial bladder cancer

目的:探讨经尿道电切术后膀胱灌注多柔比星脂质体治疗浅表性膀胱癌的临床疗效。方法:78例患者随机分为2组:表柔比星灌注组(EOX)和多柔比星脂质体组(DOL),随访比较2组患者术后复发情况和不良反应。结果:术后12个月和24个月,DOL复发率分别为5.0%和10.0%,明显低于EOX复发率18.4%和26.3%(P<0.05)。DOL组不良反应发生率低于EOX组(P<0.05)。结论:经尿道膀胱肿瘤电切术后膀胱灌注多柔比星脂质体疗效优于表柔比星而不良反应发生率低于表柔比星。

Objective：To study the curative effcet after Transurethral resection of prostate（TURP）irrigation of bladder doxorubicin lipidosome on superficial bladder cancer. Methods：All 78 patients were divided into two groups：Intravesical instillation of epirubicin group and doxorubicin lipidosome group. Results：12 months and 24 months after operation,the recurrence rate of doxorubicin lipidosome respectively were 5. 0% and 10. 0% ,significantly lower than that of epirubicin 18. 4% and 26. 3%（P 〈 0. 05）. Incidence of adverse reaction in doxorubicin lipidosome was lower than epirubicin（P 〈 0. 05）. Conclusion：The clinical curative effcet is better after TURP irrigation of bladder doxoru-bicin lipidosome than irrigation epirubicin hydrochloride,and with lower incidence of adverse reactions.