肿瘤标志物联合检测对原发性肝癌的诊断价值

Multi-tumor markers combined detection in diagnosis of primary hepatocellular carcinoma

目的:探讨肿瘤标志物(testing multi-tumor,TM)联合检测对原发性肝癌的诊断价值。方法:应用电化学发光法定量测定46例原发性肝癌患者、32例良性肝病患者、40例健康体检者血清中糖类抗原199(CA-199)、神经特异性烯醇酶(NSE)、癌胚抗原(CEA)、糖类抗原242(CA-242)、血清铁蛋白(FERR)、人绒毛膜促性腺激素(HCG)、甲胎蛋白(AFP)、游离前列腺特异性抗原(FPSA)、前列腺特异抗原(TPSA)、糖类抗原125(CA-125)、生长激素(HGH)、糖类抗原153(CA-153)12种TM的浓度。结果:肝癌组CA-199、CEA、CA-242、Ferritin、AFP、CA-153阳性率相对于良性肝病组及健康对照组显著增高(P<0.01);肝癌组CA-199、CEA、CA-242、Ferritin、AFP、CA-153联合检测相对于健康对照组阳性率及敏感性显著增高(P<0.01)。结论:CA-199、CEA、CA-242、Ferritin、AFP、CA-153联合检测有助于提高原发性肝癌阳性检出率。

Objective：To study the serum tumor markers（TM）joint detection clinical value in the diagnosis of hepatic cancer. Methods：The serum levels of 12 tumor markers,including CA - 199,NSE,CEA,CA - 242,CA -125,CA - 153,AFP,Ferritin,FPSA,PSA,β - HCG and HGH were measured in 46 cases with liver cancer,32 cases with benign liver lesion and 40 healthy canses by electrochemiluminescence ECL. Results：In liver cancer group,CA- 199,CEA,CA - 242,Ferritin,AFP,CA - 153 serum level was higher than benign liver disease group and control group（P 〈 0. 01）. In liver cancer group CA - 199,CEA,CA - 242,Ferritin,AFP,CA - 153 joint detection level was higher than benign liver disease group and control group（P 〈 0. 01）. Conclusion：The joint detection of CA - 199、CEA、CA - 242、Ferritin、AFP、CA - 153 is helpful for diagnosis of liver cancer.