吸烟与痤疮发生风险的系统评价

Correlation between Smoking and the Development of Acne: A Systematic Review

目的系统评价吸烟与痤疮发生风险的相关性。方法电子检索Cochrane图书馆,Pub Med,EMBASE,CBMdisc,CNKI和Wan Fang Data数据库,收集国内外发表的关于吸烟与痤疮发生相关性的病例对照研究,检索时间截至2014年5月,并用手工查找相关论文及专著。由两名评价员独立按照纳入与排除标准选择文献、提取资料和评价质量后,采用Stata9.0软件进行Meta分析。结果最终纳入10个病例对照研究,包括3 363例痤疮患者。方法学质量评价结果显示,总体研究质量不高。Meta分析结果显示,吸烟人群与不吸烟人群相比,其罹患痤疮的风险增加[OR合并=1.944,95%CI(1.118,3.379)]。按地域进行亚组分析,结果显示亚洲人群的OR合并为1.137[95%CI(0.560,2.309)],吸烟组和非吸烟组痤疮发生风险差异无统计学意义,但欧洲人群的OR合并为2.729[95%CI(1.198,6.215)],吸烟组和非吸烟组痤疮发生风险差异有统计学意义。结论现有临床证据表明,吸烟可增加痤疮发生的风险。

Objective To evaluate the correlation between smoking and the development of aene systematically. Meth- otis The databases including Cochrane Library, Pubmed, EMBASE, CBMdisc, CNKI and WANFANG were searched to collect the case-control studies about correlation between smoking and acne. The retrieval time was by the end of May 2014, and relevant bibliographies and abstracts of conference proceedings were also completed with hand searching. Data was extracted and assessed by two evaluators independently with a spe- cially designed extraction form. The statistical analysis was conducted using Statag. 0 software. Results A total of 10 case-control studies involving 3 363 patients with acne were included. The quality assessment indi- cated totally low. The results of meta-analysis showed that, compared with nonsmokers, smokers had an in- creased risk of the development of acne（ OR = 1. 944,95% CI 1.118 - 3. 379）. The geographical subgroup analyses showed there was no correlation in the development of acne between the smokers and nonsmokers in Asia（ OR = 1. 137,95% CI 0. 560 ~ 2. 309）, but a positive correlation was found between smokers and non- smokers in Europe（ OR =2. 729,95% CI 1. 198 - 6. 215）. Conclusion Smoking can increase the risk of the development of acne in term of current clinical evidences.