ALDH1在三阴乳腺癌组织中的表达及与预后的关系

ALDH1 expression in triple negative breast cancer tissues and its relationship with prognosis

目的:探讨ALDH1在三阴乳腺癌组织中的表达情况及其与预后的关系。方法:采用免疫组织化学方法对41例三阴乳腺癌患者的肿瘤组织进行ALDH1的检测,并通过生存分析了解ALDH1与三阴乳腺癌患者预后的关系。结果:ALDH1在三阴乳腺癌中的表达率为51.22%,且ALDH1表达阳性的三阴乳腺癌患者的5年生存率明显低于ALDH1阴性患者,其差异有统计学意义(P=0.02)。ALDH1与淋巴结转移(P=0.003)、肿瘤大小(P=0.040)存在相关性,而与患者年龄、TNM分期和病理类型无明显关系(P>0.05)。单因素统计分析显示ALDH1表达同患者年龄、淋巴结转移情况、TNM分期一样与患者5年生存率相关(P<0.05),多因素统计分析显示ALDH1也是三阴乳腺癌患者的独立预后指标(P=0.018)。结论:ALDH1在三阴乳腺癌中表达较高,提示三阴乳腺癌组织中含有较高比例的肿瘤干细胞,进一步解释了三阴乳腺癌患者容易复发及预后不良的特点。同时,ALDH1作为三阴乳腺癌肿瘤干细胞的标志物,能够预测三阴乳腺癌患者的预后,为三阴乳腺癌患者的治疗提供可靠的依据。

Objective ：To investigate the ALDH1 expression in triple negative breast cancer（TNBC） and its relationship with prognosis. Methods：We performed immunohistochemical analyses on 41 TNBC to detect ALDH1, and to study the relationship between ALDH1 and prognosis. Results： ALDH1 expression in carcinoma cells was found in 51.22% of cases. Patients with ALDH 1 expression in carcinoma cells had a shorter 5 -year survival according to the Logrank test（P =0.02）. ALDH1 expression in carcinoma cells was correlated with lymph angiogenesis （P = 0.003 ） and tumor size （ P = 0.040）, whereas it was not correlated with any other clinicopathological parameter（ P 〉 0.05 ）. According to Cox multivariate analysis, ALDH1 expression in carcinoma cells was an independent prognostic indicator of 5 -year survival（ P = 0. 018 ）. Conclusion：ALDH1 expression in carcinoma cells is an independent prognostic factor in TNBC patients.