热量限制对胶质母细胞瘤患者预后影响的前瞻性研究

Caloric restriction on the prognosis of patients with glioblastoma multiforme: a perspective study

目的确定热量限制(CR)和超低热量限制性(LCR)饮食辅助的治疗对胶质母细胞瘤(GBM)患者预后的影响。方法 50例GBM全切病例,术后均经放化疗。15例行热量限制饮食(5040-5 880 KJ/d)+心理引导+高压氧同步辅助化疗(CRPH);5例行超低热量限制饮食(2 091-2 509KJ/d)+心理引导+高压氧同步辅助化疗(LCRPH)。30例对照组病例自行设计饮食,不进行心理引导,行放化疗。随访一直持续到患者死亡。统计分析CRPH及LCRPH对GBM患者预后的改善作用,以及CRPH和LCRPH哪个作用更显著。结果 CRPH组及LCRPH组生存期均比对照组生存期长,且有显著性差异(P值分别0.000和0.000)。而CRPH组与LCRPH组生存期比较,无显著性差异(P=0.092)。结论 CRPH和LCRPH均可明显延长GBM患者的生存期;但CRPH和LCRPH对GBM预后的影响似乎无显著区别。

Objective The effects of caloric restriction （CR） and lower caloric restriction （LCR） on the prognosis of patients with glioblastoma multiforme （GBM） under total resection is discussed. Methods All the Fifteen patients were performed total resection in Beijing Tiantan Hospital and Beijing Tiantan Puhua Hospital from November in 2007 to Novermber in 2011, and all the cases were proved by molecular pathology. Thirty patients in control group underwent resections, radiotherapies and chemotherapies. Fifteen patients in experimental group were furthermore treated by CR （5 040-5 880 KJ/d ） ＋ psychotherapy ＋ chemotherapy associated with hybaroxia （CRPH）. Five patients were treated by LCR （2 091-2 509 KJ/d） ＋ psychotherapy ＋ chemotherapy associated with hybaroxia （LCRPH）. Results Either CRPH or LCRPH could improve the prognosis of GBM significantly （P 〈0. 001 and 0. 001）, but the influence of CRPH and LCRPH had no significant difference （P =0.092）. Conclusion Either CRPH or LCRPH can apparently prolong the life span of the patients with glioblastoma multiforme, but there is no significant difference between the effect of CRPH and LCRPH on the prognosis.