摘要
[目的]探讨接受血透治疗的终末期肾病(ESRD)病人血浆网膜素水平变化及其与体重指数(BMI)、血清肌酐(Scr)、血糖、血脂、胰岛素抵抗指数的关系。[方法]收集62例ESRD病人(男32人,女30人)资料,同时选取年龄匹配的肾功能正常的健康成人80例做为正常对照组。采用酶联免疫法测定空腹血浆网膜素水平,采用稳态模型评估法(Homa-IR)计算胰岛素抵抗指数,并分析血浆网膜素与BMI、血脂、血糖及Homa-IR等的关系。[结果]ESRD病人血清网膜素水平明显高于正常人(P<0.01),ESRD组伴有糖尿病者网膜素水平又明显低于无糖尿病的病人(P<0.01)。血浆网膜素水平与BMI、Homa-IR呈负相关,与高密度脂蛋白胆固醇、Scr水平呈明显正相关(r=0.424,P<0.01)。[结论]ESRD病人血浆网膜素水平较健康者升高,ESRD病人合并糖尿病者血浆网膜素水平较未合并糖尿病病人低。
Objective] To investigate plasma level of omentin in chronic hemodialysis patients and its correlation with BMI,serum creatinine,fasting glucose,blood lipid and Homa-IR. [Methods] The study included 80 health people as control group and 62 chronic hemodialysis patients .A double antibody sandwich enzyme-linked immuno sorbent assay （ ELISA ） method was applied to detect the level of serum omentin and homeostasis model assessment of insulin resistant （ Homa-IR） to assess the insulin resistance index ,analysis being done on correlation between serum omentin and other indexes . [ Results ] The levels of plasma omentin was significantly higher in hemodialysis patients than those in control group （ P〈0.01）.ESRD（end-stage renal disease） patients with diabetes had lower level of plasma omentin than those without diabetes .The serum level of omentin had negative correlation with BMI and Homa-IR, and positive correlation with HDL-C, serum creatinine . [ Conclusion] The serum level of omentin proves to be ele-vated in ESRD patients receiving hemodialysis;and those with diabetes had lower levels of plasma omentin than those without .
出处
《上海预防医学》
CAS
2015年第5期295-297,共3页
Shanghai Journal of Preventive Medicine
关键词
网膜素
终末期肾病
糖尿病
Omentin
End-stage renal disease （ESRD）
Diabetes
