静脉注射丙种球蛋白辅助治疗毛细支气管炎疗效观察

Effect of the intravenous gamma globulin in the treatment of bronchiolitis

目的:探讨丙种球蛋白辅助治疗毛细支气管炎的临床效果。方法:将毛细支气管炎患儿76例随机分为对照组44例和治疗组32例。对照组予以解痉平喘、糖皮质激素类药物及抗病毒等药物,若合并细菌感染则给予抗生素;治疗组在此基础上予以丙种球蛋白辅助治疗。比较2组患儿临床症状缓解情况及住院时间等指标。结果:治疗组患儿咳嗽、肺部哮鸣音、肺部体征消失时间及住院时间均明显短于对照组(P<0.01);治疗组总有效率93.8%,明显高于对照组的79.5%(P<0.01)。结论:丙种球蛋白辅助治疗毛细支气管炎临床疗效明显,安全性高,优于常规治疗,值得临床推广应用。

Objective：To investigate the clinical effects of gamma globulin in the treatment of bronchiolitis. Methods：Seventy-six bronchiolitis children were randomly divided into the treatment group（32 cases） and control group（44 cases）. The control group were treated with bronchodilators, anti-asthmetic drugs, glucorticoids, and anti- viral and infection, the treatment group were additionally treated with gamma globulin based on the conventional treatment. The time of clinical symptom disappearance and hospitalization between two groups were compared. Results：The time of clinical symptoms （ including cough, pulmonary wheeze and signs ） disappearance and hospitalization in treatment group were significantly shorter than those in control group（P〈0. 01）. The total effective rate in treatment group（93. 8%） was significantly higher than that in control group（79. 5%）（P〈0. 01）. Conclusions：The treatment of bronchiolitis with gamma globulima is effective and safe,which is worthy of clinical application.