结直肠癌肝转移γ-神经突触核蛋白高表达的临床意义

The clinical significance of high expression of gamma-synuclein in colorectal cancer patient with liver metastasis

目的:探讨结直肠癌(CRC)肝转移患者γ-神经突触核蛋白(SNCG)高表达的临床意义。方法:根据术后癌细胞转移情况将219例患者分为肝转移组114例和无肝转移组105例。采用免疫组织化学法,分析SNCG表达水平与CRC患者术后肝转移的关系及其与术后无病生存时间和总生存时间的关系。结果:SNCG阳性率在肝转移组为71.96%,无肝转移组为28.04%。Logistic多因素分析显示,SNCG表达是判断CRC术后是否有肝转移的独立因素(P<0.01)。SNCG阳性表达与阴性表达的肝转移患者术后无病生存时间分别为(48.70±5.40)个月和(78.75±4.23)个月,总生存时间分别为(51.10±5.20)个月和(80.29±4.12)个月,SNCG阴性患者的生存时间均明显长于SNCG阳性患者(P<0.01)。结论:SNCG表达水平越高,CRC患者术后肝转移的风险越高,无病生存期越短。CRC组织中SNCG高表达可以作为预测肝转移的指标,值得临床推广。

Objective：To investigate the clinical significance of high expression of synuclein gamma（SNCG） in colorectal cancer （ CRC） patients with liver metastases. Methods：Two hundred and nineteen patients with CRC were divided into the liver metastasis group （ 114 cases ） and non-liver metastasis group （ 105 cases ） . The relationships between the SNCG level identified by immunohistochemistry and liver metastasis, disease-free survival time after surgery and overall survival were analyzed. Results：The positive rates of SNCG in liver metastasis group and non-liver metastasis group were 71. 96% and 28. 04%,respectively. Multivariate analysis showed that the expression of SNCG in CRC patients was an independent factor of hepatic metastasis（P〈0. 01）. The disease-free survival time after surgery and overall survival in liver metastasis patients with the positive and negative SNCG expressions were （48. 70 ± 5. 40） ＆（78. 75 ± 4. 23） months and（51. 10 ± 5. 20） ＆amp;（80. 29 ± 4. 12） months,respectively. The survival time in negative SNCG patient was higher than that in positive SNCG patient（P〈0. 01）. Conclusions：With the increasing of SNCG expression,the liver metastasis and disease-free survival time in CRC patients increase and shorten, respectively. High expression of SNCG in CRC tissue can be used as a prediction index of liver metastasis.