摘要
New neurons are generated and integrate into existing circuitry within the hippocampal dentate gyrus and the olfactory bulb of most mammals （Gage and Temple, 2013）. Neurogenesis in the hippocampus persists through adulthood, and while its function and importance remains unclear, it appears to be required in the formation of specific types of learning and memory that may be compromised in neurological disorders （Gage and Temple, 2013）. A balanced translocation in Disrupted-in-Schizophrenia 1 （DISC1） was discovered in a large Scottish family with a high incidence of schizophrenia, bipolar disorder and major depressive disorder （Millar et al., 2000）, and several independent animal models demonstrate that DISC1 mediates multiple aspects of embryonic and adult neurogenesis. Here, we will discuss the data linking DISC1 to neurogenesis, and define some of the questions that remain unanswered regarding DISC1 function.
New neurons are generated and integrate into existing circuitry within the hippocampal dentate gyrus and the olfactory bulb of most mammals （Gage and Temple, 2013）. Neurogenesis in the hippocampus persists through adulthood, and while its function and importance remains unclear, it appears to be required in the formation of specific types of learning and memory that may be compromised in neurological disorders （Gage and Temple, 2013）. A balanced translocation in Disrupted-in-Schizophrenia 1 （DISC1） was discovered in a large Scottish family with a high incidence of schizophrenia, bipolar disorder and major depressive disorder （Millar et al., 2000）, and several independent animal models demonstrate that DISC1 mediates multiple aspects of embryonic and adult neurogenesis. Here, we will discuss the data linking DISC1 to neurogenesis, and define some of the questions that remain unanswered regarding DISC1 function.
基金
supported by the Wellcome Trust
JSC was funded by the Medical Research Council
