摘要
Dendrites are exquisitely specialized cellular compart- ments that critically influence how neurons receive and process information. Most synaptic inputs are received onto dendritic shafts, or small protuberances known as dendritic spines, and are then integrated and transmitted to the cell soma. During nervous system development, dendrites are dynamic, expanding and retracting rapidly, in response to intrinsic and environmental cues. Selective elimination of dendritic processes, also known as developmental pruning, ensures precise connectivity and refines neuronal networks.
Dendrites are exquisitely specialized cellular compart- ments that critically influence how neurons receive and process information. Most synaptic inputs are received onto dendritic shafts, or small protuberances known as dendritic spines, and are then integrated and transmitted to the cell soma. During nervous system development, dendrites are dynamic, expanding and retracting rapidly, in response to intrinsic and environmental cues. Selective elimination of dendritic processes, also known as developmental pruning, ensures precise connectivity and refines neuronal networks.
基金
supported by grants from the Canadian Institutes of Health Research to ADP and the Fonds de recherche du Québec-Santé(FRQS)
