摘要
白介素-22(interleukin-22,IL-22)是一种分泌蛋白,在Dumoutier等用IL-9刺激T淋巴瘤细胞系时发现,因其结构与编码基因等的相似性,归于IL-10家族,具有促进炎症反应与抵抗炎症反应的双重作用,在银屑病、溃疡性结肠炎、系统性红斑狼疮等多种炎症性疾病及自身免疫性疾病中发挥重要作用.目前研究认为,IL-22能够促进肝细胞的再生与增殖,对抗多种毒性物质造成的肝毒性和肝脏损伤,参与了肝脏疾病的发生发展过程,逐渐受到人们的关注.本文重点讨论IL-22在肝炎、肝纤维化、肝癌甚或肝功能衰竭中的作用.
Interleukin（IL）-22, which is discovered by the Dumoutier team during the stimulation of murine BW5147 T lymphoma cells with IL-9, is a member of the IL-10 cytokine family because of the similarity of structure and encoding genes. IL-22 is involved in many inflammatory diseases and autoimmune diseases, such as psoriasis, ulcerative colitis, and systemic lupus erythematosus. Recently it has been found that IL-22 can protect against liver injury and promote hepatocytes proliferation. This paper will make a brief introduction of the role of IL-22 in liver diseases.
出处
《世界华人消化杂志》
CAS
2015年第11期1770-1775,共6页
World Chinese Journal of Digestology
关键词
白介素-22
肝炎
肝纤维化
肝癌
肝衰竭
Interleukin-22
Hepatitis
Liver fibrosis
Liver cancer
Liver failure
