Z综合征的流行特点和性别差异

Prevalent characteristics and gender differences of syndrome Z

目的：调查中国呼吸睡眠暂停综合征（0sA）中Z综合征的患病特点及性别差异。方法：回顾性分析2009—09～2013—11在我科住院的所有OSA患者323例（男192例，女131例）。收集人口学基本资料、临床特点、实验室数据及多导睡眠图结果。结果：Z综合征患病率为42．1％。与非Z综合征相比，z综合征年龄偏大，男性居多，有较高的体重指数及睡眠呼吸暂停低通气指数（AHI），睡眠打鼾及呼吸暂停所占比例均高。此外，z综合征在代谢指标上均显著高于非z综合征。男性z综合征有82例（42．7％），特点与总研究人群一致。女性z综合征患病率为41．2％，但与非Z综合征AHI无显著性差异。结论：z综合征OSA与各种代谢指标的严重程度均高于非z综合征，但女性z综合征与OSA严重程度无关。临床医生对于z综合征的筛查应注意性别差异，尤其不能忽视女性轻度OSA。

Objective：To investigate the prevalent characteristics and gender differences of syndrome Z in Chinese patients with obstructive sleep apnea syndrome（OSA）. Methods： A total of 323 patients with OSA hospitalized＇in our department from Sep 2009 to Nov 2013 were selected, 192 cases were male while 131 cases were female. Demographic data, clinical characteristics, laboratory data and polysomnography of all patients were collected and reviewed. Results： The prevalence of syndrome Z was 42.1%. Individuals with syndrome Z were older and more likely to be male with higher body mass index, apnea--hypopnea index （AHI） and metabolism index than those with non--sydrome Z. The prevalence of syndrome Z in female individuals was 41.2%. But the apnea/hypopnea index in female individuals showed no significant difference between syndrome Z and non--sydrome Z groups. Conclusion： OSA and metabolism index are more serious in individuals with syndrome Z than those without syndrome Z. However, syndrome Z was not correlated to severity of OSA in females. Physicians should pay attention to gender differences in the screening of the syndrome Z, particularly those females with mild OSA.