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不孕相关精子蛋白抗体检测的临床意义 被引量：1

Clinical significance of detection of sperm protein antibody associated with infertility
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摘要 目的:分析不孕相关精子蛋白抗体与免疫性不孕的关系。方法:收集临床抗精子抗体阳性的不孕患者的外周血标本,ELISA法检测STP-4、TSA-1、SPAG7、FA-1及YLP-12与免疫性不孕相关的精子蛋白的抗体。结果:免疫性不孕相关精子蛋白的抗体阳性率仅有15%。结论:检测不孕相关精子蛋白的抗体对免疫性不孕的临床诊疗更为有益。 Objective： To analyze the relationship between sperm protein antibody associated with infertility and immune infertility. Methods：Peripheral blood samples of the clinical infertile patients with positive antisperm antibody were collected. Antibodies of some sperm proteins such as STP-4,TSA-1, SPAG7,FA-1 and YLP-12 which were associated with immune infertility were detected by ELISA. Results：The positive rate of sperm protein antibody associated with immune infertility was only 15%. Conclusion：Detection of sperm protein antibody associated with immune infertility is benefit for clinical diagnosis and treatment of immunological infertility.
作者 张宏斌 郭新宇 周霞 周烨 王捷
机构地区 广州军区广州总医院医学实验科 广州军区广州总医院生殖中心
出处 《西北国防医学杂志》 CAS 2015年第4期235-237,共3页 Medical Journal of National Defending Forces in Northwest China
基金 广东省科技计划资助项目(2012B032000011)
关键词 精子蛋白 外周血 检测 sperm protein, peripheral blood, detection
分类号 R711.6 [医药卫生—妇产科学]
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参考文献11

  • 1Bohring C L, Krause W. Immune infertility: towards a better understanding of sperm (auto) - immunity [J ]. Hum Reprod, 2003,18(5) : 915 - 924.
  • 2Shibahara H, Koriyama J, Shiraishi Y, et al. Diagnosis and treatment of immunologically infertile women with sperm-immobilizing antibodies in their sera[J]. J Re- prod Immunol2009,83(1-2) :139-144.
  • 3Bohring C, Krause W. The role of antisperm antibodies during fertilization and for immunological infertility[J]. Chem Immunol Allergy, 2005,88 : 15 - 26.
  • 4Chiu W W ,Chamley L W. Clinical associations and mech- anisms of action of antisperm antibodies[J]. Fertil Steril, 2004,82 (3) : 529 - 535.
  • 5张宏斌,武婕,王捷,周晓宁.人受精相关抗原-1的基因克隆及原核表达[J].中国优生与遗传杂志,2009,17(5):32-33. 被引量：3
  • 6周晓宁,武婕,张宏斌,王捷.重组人睾丸特异性抗原-1(TSA-1)的基因克隆及原核表达[J].中国优生与遗传杂志,2008,16(10):29-30. 被引量：1
  • 7Abou-Haila A, Tulsiani D R. Mammalian sperm acro- some : formation, contents, and function [J].Arch Bio- chem Biophys,2000,379(2) : 173- 182.
  • 8Santhanam R,Naz R K. Novel human testis-specific cD- NA:molecular cloning, expression and immunobiological effects of the recombinant protein[J]. Mol Reprod Dev, 2001,60(1) : 1- 12.
  • 9Beaton S, Cleary A, ten Have J, et al. Cloning and charac- terization of a fox sperm protein FSA- 1[J]. Reprod Fer- til Dev,1994,6(6) :761-770.
  • 10Naz R K. Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice[J]. Mol Reprod Dev, 2006,73(11) : 1473 - 1479.

二级参考文献18

  • 1Kaplan P, Naz RK. The fertilization antigen - 1 does not have proteolytic/acrosin activity, but its monoelonal antibody inhibits sperm capacitation and acrosome reaction [ J ]. Fertil Seril, 1992,58 (2) :396 - 402.
  • 2Xiaolong Zhu, Naz RK. Fertilization antigen - 1 : cDNA cloning, testis - specific expression, and immunocontraceptiveeffects [ J ]. Proc Natl Acad Sci,1997,94(9) : 4704 -4709.
  • 3Bohring C, Krause W. The role of antisperm antibodies during fertilization and for immunological infertility [ J ]. Chem Immunol Allergy, 2005,88 : 15 - 26.
  • 4Chiu WW, Chamley LW. Clinical associations and mechanisms of action of antisperm antibodies [ J ]. Fertil Steril, 2004,82 ( 3 ) :529.
  • 5Bohring C, Kranse W. Immune infertility : towards a better understanding of sperm(auto) - immunity. The value of proteomic analysis[ J]. Human Reproduction,2003,18 (5) :915 - 924.
  • 6Naz RK. Antisperm vaccine for contraception [ J ]. Am J Reprod Immunol,2005,54(6) : 378 -383.
  • 7Naz RK . Antisperm Immunity for Contraception [ J]. J Androl,2006, 27(2) :153 - 159.
  • 8Bhande S, Naz RK. Molecular identities of human sperm proteins reactive with antibodies in sera of immunoinfertile women [ J ]. Mol Reprod Dev,2007,74(3) :332 -340.
  • 9Williams J, Samuel A, Naz RK. Presence of antisperm antibodies reactive with peptide epitopes of FA - 1 and YLP12 in sera of immunoinfertile women[J]. Am J Reprod Immunol,2008,59(6) :518 -524.
  • 10[1]Santhanam R,Naz RK.Novel human testis-specific cDNA:Molecular clonging,expression and immunobiological effects of the recombinant protein[J].Mol Reprod Dev,2001,60(1):1-12.

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西北国防医学杂志
2015年 第4期

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