重度子痫前期患者分娩前后心脏损伤比较＊

Cardiac injury comparing which happened in severe preeclampsia before and after childbirth

目的:比较早发型与晚发型重度子痫前期(PE)患者的心脏损伤情况。方法:选取2012年4月至2014年5月在我院产科住院分娩的早发型及晚发型重度PE孕妇各50例,检测静脉血中心肌肌钙蛋白、心肌酶谱、脑钠肽前体含量,同时行心脏彩色多普勒超声检查。判定重度PE患者是否存在心脏损伤,并比较早发型与晚发型重度PE患者的心脏损伤程度的差异。结果:早发型及晚发型的重度PE孕妇的产前各项指标异常率均明显高于同期正常妊娠组,差异有统计学意义(P<0.05),但两种类型重度PE之间比较差异无统计学意义(P>0.05);两种类型产后各项指标均基本正常,差异无统计学意义(P>0.05)。结论:两种类型重度PE明显增加孕妇心脏损害的概率。早发型及晚发型患者产前心脏损害为可逆性。联合运用多种检测手段可早期发现重度PE患者心脏损害。

Objective：To investigate the early onset and late onset of severe preeclamp- sia cardiac injury. Methods：Select from April 2012 to May 2014 in our hospital and obstetric hospital childbirth 50 cases of early onset severe preeclampsia and 50 cases late onset, detective the content of cTnI~ cTnT, NT-proBNP, cardiac ultrasound examination, all with 1 ： 1 propor- tional selection of normal pregnancy in the same phase as compared to the control group, to de- termine severe preeclampsia the presence of cardiac damage in patients with severe preeclamp- sia. Result： Early onset and late onset of maternal heart rate of abnormal index were significant- ly higher than those of normal pregnancy group, the difference was statistically significant （P〈 0.05 ）. Early onset and late onset of maternal heart rate befor and after childbirth both were no statistically significant （ P〉0.05 ）. Conclusion ： Early onset and late onset of severe preeclamp- sia increased maternal cardiac damage probability, but the maternal cardiac damage was reversi- ble, conbond of medical treatments can strengthen pair cardiac injury of severe preeclampsia.