摘要
目的探讨STAT3和P16在人脑胶质瘤中的表达情况及临床意义。方法采取S-P免疫组化法检测STAT3和P16在10例正常脑组织、37例低级别胶质瘤(Ⅰ级、Ⅱ级)和38例高级别胶质瘤(Ⅲ级、Ⅳ级)中的表达情况,进一步探讨二者之间的关系及临床意义。结果与正常脑组织相比,STAT3蛋白在人脑胶质瘤中的表达显著增强,P16蛋白在人脑胶质瘤中的表达显著减弱。STAT3与P16在人脑神经胶质瘤中的表达呈负相关(P<0.05)。结论 STAT3高表达和P16低表达可能与人脑神经胶质瘤的发生发展有关。
Objective To explore the expression and clinical significance of STAT3 and P1 6 in human gliomas.Methods S -P immunohistochemical method was used to detect the expression of STAT3 and P1 6 in 1 0 cases of normal brain tissue and 75 cases of gliomas（37 cases in grade Ⅰ ～Ⅱ,38 cases in grade Ⅲ ～Ⅳ）.The relationship and clinical significance between STAT3 and P1 6 was analyzed.Results There was a high -level expression of STAT3 and low -level expression of P1 6 in hu-man gliomas.The expression of STAT3 was negatively correlated to P1 6（P 〈0.05）.Conclusion High expression of STAT3 and low expression of P1 6 may be associated with the occurrence and development of human gliomas.
出处
《河南医学研究》
CAS
2015年第2期7-9,共3页
Henan Medical Research
