心脏再同步化治疗对轻中度慢性心力衰竭患者心功能的影响分析

Influence of cardiac resynchronization therapy on heart function of patients with mild or moderate chronic heart failure

目的观察心脏再同步化治疗对轻中度心力衰竭患者心功能的影响。方法选择10例行心脏再同步化治疗的伴有QRS波时限延长和明显左室收缩功能下降的轻中度心力衰竭患者,于术前、术后3个月及6个月测定6 min步行距离(MHW)、QRS波时限、胸片、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)和血浆脑钠肽(BNP)。结果 10例患者均成功植入三腔起搏器,NYHA心功能分级改善不明显,6 min步行距离增加,但与术前比较,差异无统计学意义(P>0.05),QRS波时限缩短,左室射血分数明显提高,左室舒张末期内径明显减小,血浆脑钠肽水平显著下降,差异均有统计学意义(P<0.05)。结论心脏再同步化治疗可明显改善轻中度慢性心力衰竭患者的心功能。

Objective To observe the influence of cardiac resynchronization therapy on heart function of patients with mild or moderate chronic heart failure.Methods 1 0 patients with mild or moderate chronic heart failure were selected and treated with cardiac resynchronization therapy.ORS duration,chest X -ray,left ventricular ejection fraction（LVEF）,left ventricular end -diastolic diameter（LVEDD）,BNP and 6 -min walking were observed before operation as well as three and six months after oper-ation.Results All patients were implanted with three chamber pacemaker successfully.6 -min walking distances and NYHA cardiac function classification were increased insignificantly（P 〉0.05）.The index such as ORS duration,left ventricular ejection fraction（LVEF）,left ventricular end -diastolic diameter（LVEDD）,BNP were all better than before（P 〈0.05）.Conclusion Cardiac resynchronization therapy could improve the heart function of patients with mild or moderate chronic heart failure,NYHA＆amp;nbsp;grade Ⅰ ～Ⅱ.