半枝莲多糖对Lewis肺癌荷瘤小鼠的抑瘤作用研究

The Anti-Tumor Effect of Scutellaria Barbata Polysaccharides on Mice with Lewis Lung Cancer

目的：探讨半枝莲多糖（SBPS）对Lewis 肺癌荷瘤鼠的抑瘤作用。方法建立Lewis 肺癌荷瘤鼠实验模型，随机的分为5组：分别为模型组（生理盐水）、环磷酰胺（CTX）组（30 mg· kg－1· d－1）、SBPS高剂量组（200 mg· kg－1· d－1）、中剂量组（100 mg· kg－1· d－1）和低剂量组（50 mg· kg－1· d－1）。测定抑瘤率、脾指数、胸腺指数、肺／体比。结果 SBPS 抑制Lewis肺癌荷瘤鼠肿瘤与模型组相比有显著差异（ P ＜0.01）。100 mg· kg－1 SBPS对Lewis 肺癌荷瘤鼠肿瘤的抑制作用最好，抑瘤率为49.68％。 SBPS中剂量组和低剂量组可有效提高脾指数和胸腺指数、降低肺／体比。结论 SBPS对Lewis 肺癌荷瘤鼠具有明显的抑瘤作用。

Objective Establishing an experimental model of mice bearing Lewis Lung Cancer for probing into the anti -tumor effect of SBPS them.Methods We randomly divided hem into 5 groups：model group （normal saline）, CTX group （30mg· kg-1 · d-1）, SBPS high-dose group （200mg· kg-1· d-1）, SBPS middle-dose group （100mg· kg-1· d-1）and SBPS low -dose group （50mg· kg-1· d-1）,and determined the inhibitory rate, spleen index , thymus index, lung/body ratio.Results SBPS has an inhib-iting effect on the growth of tumor of mice bearing Lewis Lung Cancer , and significant difference compared to the model group （ P 〈0.01）.100mg· kg-1 SBPS has the best inhibiting effect on tumor of mice withLewis Lung Cancer , with tumor inhibition rate 49.68%.SBPS medium-dose group and low -dose group can effectively improve the spleen index and thymus index and lung /body rati-o.Conclusion SPS has a certain anti -tumor effect on mice with Lewis Lung Cancer.