S100B水平与心功能及慢性心力衰竭的相关性研究

Correlation of the SIOOB level with cardiac function and chronic heart failure

目的探讨S100B水平与心功能及慢性心力衰竭（心衰）的相关性。方法选择80例老年心衰患者为心衰组，同时选择同期健康体检者80例为对照组。确定心衰组纽约心脏病协会（NYHA）心功能分级。比较两组S100B、NT—proBNP水平，左心室舒张末内径（LVEDD）和左心室射血分数（LVEF）。分析S100B与NT-proBNP、LVEF及NYHA心功能分级水平的相关性。结果心衰组S100B（91．4±31．9）pg／L较对照组（74．9±26．0）pg／L水平升高（t=1．980，P=0．000）。NT-proBNP及LVEDD水平升高，LVEF水平降低，差异有统计学意义（均P〈0．01）。S100B水平与NT-proBNP呈正相关（r=0．309，P=0．003）；与NYHA分级呈正相关（r=0．508，P=0．001）；与LVEF呈负相关，差异有统计学意义（r=-0．192，P：0．004）。结论S100B蛋白水平在慢性心衰患者中明显升高，且与患者心功能呈负相关，对于心衰诊断和评估的有提示意义，但仍需更多的循征依据。

Objective To investigate the correlation of the S100B level with cardiac function and chronic heart failure. Methods A total of 80 elderly chronic heart failure （CHF） patients who accepted treatments in our hospital from March 2012 to December 2013 were recruited, and 80 subjects undergoing health examinations served as the control group. The New York Heart Association （NYHA） functional classification in the experimental group was determined. Serum levels of S100B and NT-proBNP, left ventricular end diastolic diameter （LVEDD） and left ventricular ejection fraction （LVEF） were compared between the groups, and the correlation of the S100B level with NT-proBNP, LVEF and the NYHA functional classification were analyzed. Results The serum S100B level was increased in the experimental group as compared with the control group [（91.4 ±31.9） pg/L w （74.9±26.0） pg/L, t=1.980, P=0.000]. The serum NT-proBNP level was higher, LVEDD was longer, and LVEF was lower in the experimental group than in the control group （all P〈0.01）. The serum S100B level was positively correlated with NT-proBNP （r=0. 309, P= 0. 003） and the NYHA functional classification （ r= 0. 508, P= 0. 001）, and negatively correlated with the LVEF （r=-0. 192, P=0. 004）. Conclusions The serum S100B level is increased in patients with CHF and negatively correlated with cardiac function, suggesting that the S100B protein may serve as a valuable tool for the diagnosis and assessment of CHF. However, more studies are needed to provide more evidence.