慢性自发性荨麻疹免疫相关指标与病情的相关性分析

Correlation between Autoimmune Index and the Severity of Chronic Spontaneous Urticaria

目的:探讨慢性自发性荨麻疹(CSU)患者免疫相关指标:ASST、总IgE、免疫五项及甲状腺自身抗体与CSU病情的相关性。方法:收集79例确诊为CSU患者的血清标本,检测ASST、IgE、C3、C4、IgA、IgM、IgG及甲状腺自身抗体(TPOAB、TGAB)水平,采用UAS7法评估患者病情,分析各指标与病情的相关性,并与正常对照组30例比较。结果:79例患者中ASST阳性率为54%,ASST、血清总IgE、C3、C4、IgA、IgM、IgG、TPOAB及TGAB水平与UAS7评分均无相关性(P值均>0.05)。病情为轻度的患者血清C3水平明显低于中度,差异有统计学意义(P<0.05)。与正常对照组比较,CSU患者各指标中仅总IgE水平高于正常对照组,差异存在统计学意义(P<0.05)。结论:补体C3水平可为评估CSU患者病情提供一定的参考价值。

Objective：To observe the relationship between autoimmune index and the severity of Chronic spontaneous urticaria.Methods：The serum levels of ASST, IgE, C3, C4, IgA, IgM, IgG,TPOAB and TGAB of 79 patients with Chronic spontaneous urticaria were detected.UAS7 method was used to evaluate the severity of 79 patients, and the correlation between the index a-bove and degree were analyzed.Results：The positive rate of ASST was 54%.There were no corre-lation between the expression of ASST,IgE,C3,C4,IgA,IgM,IgG,TPOAB,TGAB and the UAS7 scores of chronic spontaneous urticaria （ P〉0.05 ） .Significant differences were found between the C3 concentrations of the mind degrees of urticaria severity and the moderate degrees（P〈0.05）. Conclusion：To some extent, the expression of C3 could provide some reference to the severity of chronic spontaneous urticaria.