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沙眼衣原体与宿主细胞作用相关信号通路的研究进展 被引量：1

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摘要 沙眼衣原体感染引起的泌尿生殖系统感染是近年来较常见的性传播疾病之一.据统计,2012年美国沙眼衣原体感染者约为140万例,感染率达456.7/10万[1].目前,沙眼衣原体的致病机制尚不明确.学者普遍认为,沙眼衣原体致病主要基于其诱发的宿主免疫病理损伤.受感染的生殖系统上皮细胞可分泌大量趋化因子和细胞因子,趋化特异性免疫细胞聚集,激活炎性反应及诱导特异性免疫应答,在抵御感染的同时导致细胞增殖、组织重构及瘢痕形成等病理结局[2].目前认为,沙眼衣原体的持续感染是引起宿主慢性炎性反应并导致严重后遗症及上述病理结局的重要原因.
作者 郭媛丽 刘全忠
机构地区 天津医科大学总医院皮肤科
出处 《中华传染病杂志》 CAS CSCD 北大核心 2015年第4期247-249,共3页 Chinese Journal of Infectious Diseases
基金 国家自然科学基金资助项目（31370211）
关键词 沙眼衣原体感染 泌尿生殖系统感染 信号通路 细胞作用 宿主 特异性免疫应答 免疫病理损伤 致病机制
分类号 R691.3 [医药卫生—泌尿科学]
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中华传染病杂志
2015年 第4期

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