干细胞治疗椎间盘退变性疾病:现状与展望

Stem cell therapy for degenerative disc diseases:present status and prospects

背景:目前关于椎间盘退变性疾病的治疗方案均未关注于缓解或逆转椎间盘退变的病程,近年来越来越多的研究正在尝试使用干细胞治疗椎间盘退变性疾病。目的:综述干细胞治疗椎间盘退变性疾病的现状、展望与挑战。方法:由第一作者应用计算机检索Pub Med数据库中相关文献,检索时限为2004年1月至2014年12月。检索英文主题词"stem cell,intervertebral disk"。选择文章内容与干细胞治疗椎间盘退变性疾病有关者,同一领域文献则选择近期发表在权威杂志的文章。结果与结论:初检得到文献342篇,选择符合纳入标准的43篇文献进行综述。将干细胞与载体结合后注射到退变的椎间盘是一种全新的治疗方案。目前适用于干细胞疗法的候选细胞包括:胚胎干细胞、诱导多能干细胞、间充质干细胞、人脐带间充质干细胞及类软骨细胞或髓核细胞。未来干细胞疗法的临床应用需克服以下风险:细胞泄露、椎间盘感染及肿瘤化,但其应用于治疗椎间盘退变性疾病的前途将不可估量。

BACKGROUND： None of the current treatment strategies has been focused on relieving or reversing the disk degeneration process after degenerative disc diseases. In recent years, more and more scientists try to treat degenerative disc diseases using stem cell therapy.OBJECTIVE： To explore the research status and prospects of stem cell therapy for degenerative disc diseases.METHODS： A computer-based online search of Pub Med database between January 2004 and December 2014 was performed to search related articles with the key words of ＂stem cell, intervertebral disk＂ in English.Literatures related to stem cell therapy for degenerative disc diseases were selected; in the same field, the articles published lately in authoritative journals were preferred.RESULTS AND CONCLUSION： A total of 342 articles were primarily selected, and 43 articles were involved in result analysis according to inclusion criteria. Stem cell therapy is a newly treatment for degenerative disc diseases. Cells appropriate for stem cell therapy include embryonic stem cells, induced pluripotent stem cells,mesenchymal stem cells, human umbilical cord mesenchymal stem cells and chondrocytes or nucleus pulposus cells. Although cell leakage, intervertebral disc infection and tumorigenesis are the main challenges, stem cell therapy for degenerative disc diseases is promising in the future.