平阳霉素局部注射治疗咽喉部血管瘤22例

Twenty-two Cases of Pingyangmycin Local Injection for Laryngopharyngeal and Laryngeal Hemangioma

目的探讨平阳霉素在显微支撑喉镜下局部注射治疗咽喉部血管瘤的效果。方法咽喉部血管瘤患者44例,随机分为治疗组和对照组各22例。对照组显微支撑喉镜下血管瘤体内注射博来霉素5 mg,治疗组显微支撑喉镜下血管瘤体内注射平阳霉素,一次4~8 mg,注射1次,未愈者,间歇15 d重复注射,一般不超过3次。比较两组的疗效及不良反应。结果治疗组和对照组总有效率分别为95.4%,59.1%（P〈0.05）,两组均未发生严重不良反应。结论平阳霉素局部注射治疗咽喉部血管瘤,疗效好,不良反应少。

Objective To study the therapeutic effect of pingyangmycin local injection under suspension microlaryngoscopy for treatment of laryngopharyngeal and laryngeal hemangioma. Methods The total of 44 cases of patients with laryngopharyngeal or laryngeal hemangioma were randomly divided into the experimental group （ n=22 ） and the control group （n=22）. They were treated with bleomycin 5 mg or pingyangmycin 4-8 mg injection under suspension microlaryngoscopy in the hemangioma, respectively. If the treatments were not curative, repeated one more times in intermittent 15 d, but not more than 3 times. Therapeutic effect and adverse effect were recorded and analyzed. Results The total effective rate （95. 4%）in the experimental group was significantly better than that （59. 1%） in the control group （P〈0. 05）,and side reaction in two groups showed no significant variation. Conclusion Pingyangmycin local injection for treating laryngopharyngeal and laryngeal hemangioma is effective, less adverse reaction.