杨梅素的半合成

Semisynthesis of Myricetin

以二氢杨梅素(DMY)为原料,经在碱性条件下开环和氧化成环反应半合成杨梅素,其结构经1H NMR,13C NMR和IR确证。在最佳反应条件[DMY 1.624 mmol,H2O(30 m L)为溶剂,依次加入15%H2O20.68 m L和16%Na OH溶液5.5 m L,于35℃反应24 h]下,收率16.21%。

Myricetin was synthesized by ring-opening reaction under alkaline conditions and oxidative cyclization from Dihydromyricetin. Under the optimum reaction conditions[DMY 1. 624 mmol,H2O（ 30 mL） as the solvent,adding 15% H2O20. 68 mL and 16% Na OH aqueous solution 5. 5 mL in order,at 35 ℃ for 24 h],the yield was 16. 21%.