低分子右旋糖酐与白蛋白对小儿肾病综合征远期复发性干预的临床价值

The clinical study of low molecular dextran and albumin on long term recurrence of children with nephrotic syndrome

目的 探讨用低分子右旋糖酐与白蛋白对肾病综合征（NS）患儿免疫功能低下状态及远期复发干预的临床价值.方法 选取2010～2013年收治的227例NS免疫功能低下患儿,将患儿分成对照组与观察组,对照组患儿用呋塞米（1.5～2mg/kg·次）和白蛋白（1g/kg·次）进行治疗,观察组患儿采用呋塞米（1～2mg/kg·次）和低分子右旋糖酐（10～15ml/kg·次）进行治疗.结果 观察组治疗后在疾病复发与感染方面低于对照组,治疗后IgA、IgG水平改变显著高于对照组患儿.结论 NS患儿采用低分子右旋糖酐比用白蛋白进行治疗,能够促进NS患儿的免疫情况得到明显改善,复发与感染的发生率得到明显降低。

Objective To investigate the clinical therapeutic effect of low molecular dextran and albumin on chil- dren with nephrotic syndrome （NS） with low immunity state. Methods 227 children with nephrotic syndrome with low immune function were randomly divided into control group and observation group. The control group were treated by Furosemide and albumin. Children of observation group added Furosemide and low molecular dextran. Results The recurrence and infection of observation group were lower than those of the control group. After treatment, the IgA and IgG levels of the control group were significantly higher than that of control group. Conclusion Low molecular dextran and albumin can promote immune status of children with NS and promote the probability of recurrence and the infection is significantly reduced.