甲氨蝶呤联合米非司酮治疗异位妊娠的效果分析

The effect and its influencing factor of ectopic pregnancy treated with methotrexate combined with mifepristone

目的 探讨影响甲按蝶呤联合米非司酮治疗异位妊娠效果的相关因素.方法 选择2009年1月～2013年6月在我院住院治疗的异位妊娠患者110例,按治疗方法不同分成：MTX＋ RU486组50例和MTX组60例两组,对两组患者的治疗效果及副作用进行比较,并用Logistic回归分析影响联合用药治疗效果的因素.结果 MTX＋ RU486组治疗异位妊娠的有效率为94.00％,MTX组为81.67％,差异有统计学意义（P＜0.05）.在治疗成功患者中,MTX＋RU486组血β-HCG降至阴性所需时间少于MTX组,差异有统计学意义（P＜0.05）.两组患者用药后不良反应的发生率差异无统计学意义（P＞0.05）.Logistic回归分析影响联合用药组治疗效果的唯一因素是β-HCG水平.结论 甲氨蝶呤联合米非司酮治疗异位妊娠,成功率高,疗程短,安全可靠,值得临床推广应用。

Objective To compare the effect and side-reaction of MTX＋ RU486 with MTX in treatment of ectopic pregnancy and study the related factors affecting MTX＋ RU486 treatment. Methods 110 patients diagnosed as ectopic pregnancy were recruited in this study. According to the two different treatment methods, they were assigned into MTX ＋ RU486 group （50 patients） and MTX group（60 patients ）. The effect and side-reaction of the two groups were compared and Logistic model analysis of multiple factors was used to study the prognostic factors of MTX＋ RU486 treatment. Results The effective rates in MTX＋ RU486 group and MTX group were 94.00% and 81. 67% respectively, the difference was significant（P〈0.05）. The time of β-HCG to negative of MTX＋ RU486 group were less than MTX group in successful treatment patients, the difference was significant（P〈0.05）. The only factor on the effect of MTX＋ RU486 group was the level of the β -HCG in Logistic model analysis of multiple factors. Vice-reaction were not signifi- cantly different. Conclusion The methods using MTX＋ RU486 to treat ectopic pregnancy has the advantages of high effective rates, short course of treatment, safe and reliable, worthy of clinical application.