锌缺乏与轻度胃肠炎伴婴幼儿良性惊厥的关系

The correlation of zinc deficiency and benign infantile convulsions associated mild gastroenteritis

目的探讨锌缺乏与轻度胃肠炎伴婴幼儿良性惊厥(BICE)的关系。方法轻度胃肠炎伴婴幼儿良性惊厥(BICE)组32例,普通胃肠炎组36例,健康体检儿童30例,3组儿童均空腹抽取静脉血测定血锌水平,比较3组儿童血锌水平。同时BICE组及普通胃肠炎组进行血清神经元特异性烯醇化酶(NSE)测定,比较两组NSE水平。结果 BICE组NSE水平高于普通胃肠炎组(P<0.05)。BICE组、普通胃肠炎组血锌水平均低于健康对照组(均P<0.05),BICE组患儿血锌水平亦低于普通胃肠炎组(P<0.05)。结论 BICE患儿存在神经元损伤,锌的缺乏可能参与或促使轻度胃肠炎患儿良性惊厥的发生,因此对胃肠炎患儿应积极进行补锌治疗。

Objective To study the correlation of zinc deficiency and benign infantile convulsions associated mild gastroenteritis （BICE）. Methods The children were divided into BICE group （32 cases）, common gastroenteritis group （36 cases） and healthy children （30 cases）. The children were fasting venous blood samples to measured blood levels of zinc, which were compared between the three groups of children. The serum neuron specific enolase （NSE） of children was compared between the BICE group and the common gastroenteritis group. Results The level of NSE in BICE group was higher than that of the common gastroenteritis group （P〈0.05）. The blood zinc levels in BICE group and the com- mon gastroenteritis group were lower than that of the healthy control group （P〈0.05）. The blood zinc levels in BICE group was lower than that of with common gastroenteritis group （P〈0.05）. Conclusion Children with BICE have neu- ronal damage. Zinc deficiency may be involved or promote benign convulsion in children with mild gastroenteritis. Therefore, zinc supplementation is necessary for children with gastroenteritis.