临床药师药学干预呼吸内科抗生素使用的研究

Influence of clinical pharmacists' pharmaceutical intervention on reasonable use of antibiotics in department of respiratory medicine

目的探讨临床药师药学干预对呼吸内科合理使用抗生素的影响。方法随机抽取临床药师药学干预前后呼吸内科病例资料各300份,比较干预前后抗生素使用情况、抗感染效果、合理使用等差异。结果干预后抗生素使用率明显低于干预前(71.3%VS 95.7%,P=0.000);单联抗生素使用率明显高于干预前(28.7%VS 19.0%,P=0.028),三联及以上抗生素明显低于干预前(20.0%VS 43.3%,P=0.000);平均住院费用明显少于干预前[(1965.7±265.7)VS(2600.8±316.5)元,P<0.01];抗生素使用不合理性明显低于干预前(20.1%VS 34.2%,P<0.01)。结论临床药师药学干预可促进呼吸内科合理使用抗生素,指导医生用药行为。

Objective To investigate the effect of clinical pharmacists ’pharmaceutical intervention on reasonable use of antibi-otics in department of respiratory medicine .Methods The clinical data of 300 cases before and after clinical pharmacists ’pharmaceuti-cal intervention were randomly collected .The differences in application of antibiotics ,anti-infection effect and reasonable use before and after intervention were compared.Results After the intervention,antibiotics usage were significantly lower （71.3% vs 95.7%,P =0.000）,single union antibiotics usage was significantly higher （28.7%vs 19.0%,P =0.028） and sanlian and above antibiotics were significantly lower（20.0%vs 43.3%,P =0.0001） when compared to before the intervention .The hospitalization cost was also signifi-cantly less than before intervention（1965.7 ±265.7）yuan vs （2600.8 ±316.5 yuan）].The irrational antibiotic use was significantly lower than before intervention（20.1% vs 34.2%）.Conclusion Clinical pharmacists’pharmaceutical intervention can promote rea-sonable use of antibiotics ,and regulate behavior of doctor ’s medication .