1Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment ofacute ischemic stroke. N Engl J Med, 2007 , 357(6) : 562-571.
2Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemicstroke. N Engl J Med, 2006, 354(6) : 588-600.
3Lees KR,Bluhmki E,von Kummer R, et al. Time to treatment withintravenous alteplase and outcome in stroke : an updated pooledanalysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.Lancet, 2010,375(9727) : 1695-1703.
4Hacke W,Kaste M,Bluhmki E,et al. Thrombolysis with alteplase3to 4. 5 hours after acute ischemic stroke. N Engl J Med, 2008 ,359(13) : 1317-1329.
5Albers GW, Olivot JM. Intravenous alteplase for ischaemic stroke.Lancet, 2007,369(9558) : 249-250.
6del Zoppo GJ. Stroke and neurovascular protection. N Engl J Med,2006, 354(6); 553-555.
7del Zoppo GJ. Inflammation and the neurovascular unit in the settingof focal cerebral ischemia. Neuroscience, 2009, 158(3) : 972-982.
8Mabuchi T, Lucero J, Feng A, et al. Focal cerebral ischemiapreferentially affects neurons distant from their neighboringmicrovessels. J Cereb Blood Flow Metab, 2005 , 25(2) : 257-266.
9Milner R, Hung S,Wang X,et al. Responses of endothelial celland astrocyte matrix-integrin receptors to ischemia mimic thoseobserved in the neurovascular unit. Stroke, 2008 , 39 ( 1 ) : 191-197.
10del Zoppo GJ. The neurovascular unit in the setting of stroke. JIntern Med, 2010,26(2) : 156-171.
1Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults [ J ]. JAMA, 2013,310 ( 9 ) : 948 -959.
2American Diabetes Association. Standards of medical care in diabetes-2011 [ J ]. Diabetes Care, 2011,34 ( Suppl 1 ) : S11-61.
3Wilkinson C P, Ferris F L, Klein R E, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales [ J ]. Ophthalmolo- gy, 2003,110(9) :1677-1682.
4Oyibo S O, Jude E B, Tarawneh I, et al. A comparison of two diabetic foot ulcer classification systems : the Wag- ner and the University of Texas wound classification sys- tems[ J]. Diabetes Care, 2001,24(1 ) :84-88.
5Ahmad W, Khan I A, Ghaffar S, et al. Risk factors for diabetic foot ulcer [ J ]. J Ayub Med Coil Abbottabad, 2013, 25(1-2) :16-18.
6Morettini M, Storm F, Sacchetti M, et al. Effects of walking on low-grade inflammation and their implications for Type 2 Diabetes[J]. Prey Med Rep, 2015,2: 538- 547.
7Al-Rubeaan K, A1 Derwish M, Ouizi S, et al. Diabetic foot complications and their risk factors from a large retro- spective cohort study [J]. PloS One, 2015, 10 (5):e0124446.
8Knappe S, Stoll D, Bambi M T, et al. Diabetic retinopa- thy and diabetic foot syndrome in patients of a sub-Saha- ran megacity (Kinshasa, DR Congo) [ J ]. Klan Monbl Augenheilkd, 2013,230( 1 ) :64-71.
9Kramer C K, Rodrigues T C, Canani L H, et al. Diabet- ic retinopathy predicts all-cause mortality and cardiovas- cular events in both type 1 and 2 diabetes: meta-analysis of observational studies [ J ]. Diabetes Care, 2011, 34 (5) :1238-1244.
10Rosenson R S, Fioretto P, Dodson P M. Does microvas- cular disease predict macrovascular events in type 2 dia- betes ? [ J ]. Atherosclerosis, 2011,218 ( 1 ) : 13 - 18.
