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Rho家族在肾脏足细胞细胞骨架调节中的作用 被引量：1

Rho family and the regulation of podocyte cytoskeleton
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摘要 足细胞在肾小球疾病的发生和发展中有重要地位,尤其局灶性节段性肾小球硬化症(focal segmental glomerulosclerosis,FSGS)等。FSGS作为一种典型的足细胞病,其损伤可以发生在多个环节上,包括细胞骨架(cytoskeleton)的破坏、细胞核内转录因子的异常、胞浆内线粒体能量代谢异常、细胞内钙离子动态稳定性的改变及裂孔隔膜上其他成分的异常等,其中足细胞骨架结构的变化是FSGS重要的发病机制。细胞骨架是真核细胞维持生命活动的重要成分,Rho家族(如Rho A、Cdc42、Rac1等)在细胞骨架动态变化调节中发挥着重要的作用。Rho家族蛋白介导的信号通路异常可能影响足细胞的细胞骨架稳定,进而破坏足细胞的正常结构,从而导致FSGS的发生和进展。
作者 贺蓉 李贵森
机构地区 遵义医学院 四川省医学科学院.四川省人民医院肾脏内科
出处 《实用医院临床杂志》 2015年第3期183-186,共4页 Practical Journal of Clinical Medicine
基金 国家重点基础研究发展计划(973计划)基金资助项目(编号:2012CB517604)
关键词 局灶性节段性肾小球硬化症 细胞骨架 Rho家族
分类号 R692.6 [医药卫生—泌尿科学] R394.2 [医药卫生—医学遗传学]
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参考文献34

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共引文献6

同被引文献21

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实用医院临床杂志
2015年 第3期

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