酪氨酸激酶抑制剂治疗中停药问题及根除慢性髓系白血病干细胞的治疗选择

Report on Recent Discontinuation of Tyrosine Kinase Inhibitors and Alternative Approaches of Eradicating the Chronic Myeloid Leukemia Stem Cells

酪氨酸激酶抑制剂(TKI)的临床应用极大程度地改善了慢性髓系白血病(CML)的临床疗效,使众多CML患者从中获益,TKI治疗后达到持续完全分子生物学缓解(CMR)的患者停药是否安全,目前仍有争议。TKI治疗后清除残留白血病干细胞、防止CML复发的解决方案,特别是针对CML干细胞的靶向治疗应用研究可能有望使CML患者达到长期无病生存,甚至治愈,目前已成为人们近年来关注的重点。现就TKI停药选择以及清除CML干细胞的研究相关进展进行报道。

Tyrosine kinase inhibitor （ TKI） may significantly improve the treatment outcome in chronic myeloid leukemia（ CML）.It is the most frequent question about whether thepatients with durable completemolecular response（ CMR） can safely discontinue TKI treatment without relapse.This has focused attention on the strategies to eradicate residual CML cells, especially the CML stem cells, which should result in long termleukemia-freesurvival and permanent cure.Here, the progress on discontinuation of TKI therapy andalternative approa-ches of eradicating CML stem cells is reviewed.