杜仲腰痛丸对腰椎间盘突出症患者血清TNF-α、IL-1β的影响

The Effect of DuZhongYaoTong Wan on the Levels of TNF-α and IL-1β in Patients with Lumbar Disc Herniation

目的:观察杜仲腰痛丸对腰椎间盘突出症(LDH)患者血清肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)的影响。方法:选择LDH患者共145例,治疗组76例,对照组69例,另选参加健康体检的成年人70例作为正常组。服药3周后,评定疗效,应用视觉模拟评分法进行疼痛评分,用放免法测定患者血清TNF-α、IL-1β含量。结果:TNF-α、IL-1β血清含量治疗后2组较治疗前明显下降(P<0.05),治疗组下降更明显(P<0.05)。2用药组均取得较好疗效,治疗后疼痛评分均有明显改善(P<0.05),治疗后2组间总有效率及疼痛评分比较,差异均有统计学意义(P<0.05)。结论:应用杜仲腰痛丸治疗LDH可取得较好疗效,其作用机理可能在于有效干预LDH患者炎症介质TNF-α、IL-1β表达。

To observe the effect ofDuZhongYaoTongWanon serum levels of tumor necrosis fac-tor-α（TNF-α） and interleukin-1β（IL-1β） in patients with lumbar disc herniation （LDH）. Methods： Totally 145 patients with LDH were randomly divided into the treatment group with 76 cases, and the control group with 69 cases. Another 70 adults who participated in physical examination were selected as the normal group. The efficacy was evaluated after takingDuZhongYaoTongWanfor three weeks. Visual analogue scales （VAS） were used to assess the score of pain and radioimmunoassay was applied to measure the contents of serum TNF-αand IL-1β. Results： The serum levels of TNF-αand IL-1βsignificantly increased in the patient group compared with the normal group （P〈0.01）. The serum levels of TNF-αand IL-1βsignificantly decreased in the treatment group compared with that before the treatment （P〈0.05）. The serum levels of TNF-αand IL-1βdecreased in the control group compared with that before treating （P〈0.05）. Two patient groups both obtained good efficacy, indicating significant improvements of pain scores after the treatment （P〈0.05）, and differences in total effective rate and pain scores between two groups after the treatment （P〈0.05）. Conclusion：DuZhongYaoTongWanshows a desirable clinical efficacy and analgesic effect on patients with LDH. The possible mechanism rests on the effective intervention in the expression of inflammatory mediators TNF-αand IL-1β.