归蛭通络汤联合西药治疗下肢动脉硬化闭塞症37例

Observation on Therapeutic Effects of GuiZhi TongLuo Tang and Western Medici ne in Treating 37 Cases of Lower Extremity Arteriosclerotic Occlusive Disease

目的:观察归蛭通络汤联合棓丙酯、拜阿司匹林、烟酸占替诺治疗下肢动脉硬化闭塞症(LEAOD)的临床疗效。方法:将74例患者随机分为2组。对照组37例给予棓丙酯静脉点滴,拜阿司匹林、烟酸占替诺口服。治疗组37例在对照组治疗的基础上加用归蛭通络汤治疗。2组疗程均为2个月,随访3个月,检测2组患者治疗前后足趾动脉压、踝肱指数(ABI)、血液流变学(血浆黏度)等变化,评定临床疗效。结果:总有效率治疗组为94.59%,对照组为81.08%,2组比较差异有统计学意义(P<0.05);治疗后治疗组足趾动脉压、ABI、血浆黏度变化均较对照组改善明显(P<0.05)。结论:归蛭通络汤联合棓丙酯、拜阿司匹林、烟酸占替诺治疗LEAOD的疗效优于单纯西药治疗,且副作用相对较少。

To observe the clinical efficacy ofGuiZhiTongLuoTangcombined with propylgallate, bayaspirin and xanthinol nicotinate in the treatment of lower extremity arteriosclerotic occlusive disease （LEAOD）. Methods： All 74 cases were randomly divided into the treatment group and the control group. 37 cases in the control group were given propylgallate injection, oral aspirin and xanthinol nieotinate, and 37 cases in the treatment group were treated, on the basis of the same therapy as the control group, withGuiZhiTongLuoTang. After 2-month thera-peutic courses and 3-month follow-up, changes of plantar arterial pressure, ankle-brachial index （ABI） and hemorheology （plasma viscosity） in two groups before and after treatment were detected to evaluate clinical efficiency. Results： Total effective rate was 94.59% in the treatment group and 81.08% in the control group, with a significant difference between the two groups （P〈0.05）; the plantar arterial pressure, ABI and hemorheology （plasma viscosity） in the treatment group after treating significantly improved compared with the control group （P〈0.05）. Conclusion： The clinical efficacy of GuiZhiTongLuoTang combined with propylgallate, bayaspirin as well as xanthinol nieotinate in the treatment of LEAOD is superior to that of simple Western medicine, with minor side-effects.